Efficient electrochemical determination of dopamine in the presence of uric acid in real samples using tungsten disulfide nanostructure modified electrode

Original: https://doi.org/10.5599/admet.2968

Background and purpose: Detecting uric acid (URA) and dopamine (DPA) is difficult because their signals appear very close to each other. Tungsten disulfide nanostructures are promising electrode materials because they are low-toxic, inexpensive, easy to make, and highly active.

Experimental approach: We developed an electrochemical sensor by modifying a glassy carbon electrode with tungsten disulfide nanostructures for voltammetric detection.

Key results: Electrochemical tests showed that the sensor performed very well. It could detect dopamine over a wide range (0.03–600.0 μM) and had a very low detection limit of 10 nM.

Conclusion: The sensor successfully detected the compounds in real samples, such as injections and urine, with good recovery rates, demonstrating its practical usefulness. This work provides a simple and effective way to make tungsten disulfide-modified electrodes and shows strong potential for future use in bioanalytical sensing and clinical diagnostics.